The routine management of pulmonary nodules includes biopsy and pneumonectomy. Complications such as pneumothorax and hemothorax are easy to occur during biopsy. There are risks of tumor cell shedding and metastasis. It is difficult to realize diagnosis because of the small amount of routine biopsy tissue. Pulmonary resection is not the most appropriate treatment option for elderly patients who are intolerant to anesthesia, special weakness population, postoperative recurrence, recurrence of nodules and metastases. With the continuous development of medical science and technology, tumor treatment has entered an era of "accurate diagnosis and treatment".  Cryoablation is a new diagnosis and treatment method for pulmonary nodules, and it is suitable for the ablation of solid tumors in many parts under the frozen state. Lung: After cryoablation of pulmonary nodules and rewarming, multi-angle biopsy can be performed to increase the amount of biopsy tissue to confirm the diagnosis of pulmonary nodules. Cryoablation combined with chemoradiotherapy can improve the overall survival rate and the quality of life of patients with advanced non-small cell lung cancer. Liver: It is a safe, effective and minimally invasive treatment for patients with primary liver cancer cells or metastatic liver cancer. The long term survival rate and short term efficacy of cryoablation combined with chemoembolization in the treatment of primary hepatocellular carcinoma were significantly improved. Kidney: It has less damage to collagen fibers and has advantages in ablating tumors adjacent to the capsule or the renal hilar gathering system. The advantage is more obvious when patients need conservative treatment due to poor renal function, multiple renal tumors or tumor recurrence. Breast: A common indication in breast diseases is fibroadenoma. To reduce scarring and breast deformation, especially in young women, cryoablation is a good option. It is safe for the treatment of breast tumor, small damage, quick recovery after surgery, and good cosmetic effect. Bone and soft tissue: It is mostly used for conservative treatment of bone and soft tissue tumors, which has the advantages of less trauma and high safety, and plays an important role in local tumor control and pain relief. It is especially advantageous for tumors close to the envelope and blood vessels. Overview of cryoablation process